Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4521821 | 0.87 | KMT2A (1.00) | KMT2AALDH1A1MAPTPOLBCYP3A4 | |
| SCHEMBL3534971 | 0.85 | ALDH1A1 (0.76) | KMT2AALDH1A1MAPTPOLBCYP3A4 | |
| SCHEMBL3534966 | 0.85 | ALDH1A1 (0.76) | KMT2AALDH1A1MAPTPOLBCYP3A4 | |
| SCHEMBL4513013 | 0.83 | ALDH1A1 (0.72) | KMT2AALDH1A1MAPTPOLBCYP3A4 | |
| SCHEMBL4513008 | 0.83 | ALDH1A1 (0.72) | KMT2AALDH1A1MAPTPOLBCYP3A4 | |
| SCHEMBL5982477 | 0.75 | ALDH1A1 (0.74) | KMT2AALDH1A1MAPTPOLBCYP3A4 | |
| SCHEMBL5982557 | 0.75 | ALDH1A1 (0.74) | KMT2AALDH1A1MAPTPOLBCYP3A4 | |
| SCHEMBL5984080 | 0.75 | ALDH1A1 (0.74) | KMT2AALDH1A1MAPTPOLBCYP3A4 | |
| SCHEMBL5804011 | 0.72 | ALDH1A1 (0.56) | KMT2AALDH1A1MAPTPOLBCYP3A4 | |
| SCHEMBL5804014 | 0.72 | ALDH1A1 (0.56) | KMT2AALDH1A1MAPTPOLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054460-A1 | Piperazine derivatives and methods of use | CHEN JIAN J | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054460-A1 | Piperazine derivatives and methods of use | PTGES, PTGES2, PTGIS | KMT2A 2982/4885ALDH1A1 184/4885MAPT 3351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.