Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 15/20 | 0.50 |
| ▸ | KDR | P35968 | 11/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.44 |
| ▸ | FLT1 | P17948 | 3/20 | 0.44 |
| ▸ | KIT | P10721 | 5/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL452389 | 0.84 | AURKB (0.55) | PDGFRAKDRAURKBFLT1KIT | |
| SCHEMBL453312 | 0.77 | AXL (0.49) | KDRMETAXL | |
| SCHEMBL453854 | 0.75 | KDR (0.46) | PDGFRAKDRMETAXL | |
| SCHEMBL15880261 | 0.74 | KDR (0.66) | KDRAURKBFLT1METRET | |
| SCHEMBL3869673 | 0.70 | KDR (0.66) | KDRAURKBFLT1METRET | |
| SCHEMBL5825085 | 0.69 | PDGFRA (0.74) | PDGFRAKDRAURKBFLT1KIT | |
| SCHEMBL7482697 | 0.69 | PDGFRA (1.00) | PDGFRAKDR | |
| SCHEMBL3861103 | 0.69 | KDR (0.71) | KDRAURKBFLT1METAURKA | |
| SCHEMBL469355 | 0.69 | AURKB (0.57) | PDGFRAKDRAURKBFLT1KIT | |
| SCHEMBL1877129 | 0.68 | PDGFRA (0.92) | PDGFRAKDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621904-A2 | COMPOUNDS AS C-MET KINASE INHIBITORS | Advenchen Laboratories, LLC (US) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012034055-A2 | COMPOUNDS AS C-MET KINASE INHIBITORS | ADVENCHEN LABORATORIES, LLC (US) | 2012-03-15 | — | — | WO | disclosed |