Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 8/20 | 0.49 |
| ▸ | MET | P08581 | 13/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL453854 | 0.89 | KDR (0.46) | AXLMETKDR | |
| SCHEMBL29487185 | 0.82 | AXL (0.60) | AXLMETKDR | |
| SCHEMBL22959946 | 0.82 | AXL (0.60) | AXLMETKDR | |
| SCHEMBL3693433 | 0.79 | MET (0.49) | AXLMETKDR | |
| SCHEMBL452389 | 0.78 | AURKB (0.55) | AXLMETKDR | |
| SCHEMBL15880261 | 0.78 | KDR (0.66) | METKDR | |
| SCHEMBL452388 | 0.77 | PDGFRA (0.50) | AXLMETKDR | |
| SCHEMBL381569 | 0.75 | PTGDR2 (0.42) | METKDR | |
| SCHEMBL166914 | 0.75 | AXL (0.67) | AXLMETKDR | |
| SCHEMBL18209921 | 0.74 | PTGDR2 (0.42) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621904-A2 | COMPOUNDS AS C-MET KINASE INHIBITORS | Advenchen Laboratories, LLC (US) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012034055-A2 | COMPOUNDS AS C-MET KINASE INHIBITORS | ADVENCHEN LABORATORIES, LLC (US) | 2012-03-15 | — | — | WO | disclosed |