Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | MET | P08581 | 16/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL453312 | 0.89 | AXL (0.49) | KDRMETAXL | |
| SCHEMBL29487156 | 0.84 | PDGFRA (0.53) | KDRPDGFRAMETAXL | |
| SCHEMBL22959969 | 0.84 | PDGFRA (0.53) | KDRPDGFRAMETAXL | |
| SCHEMBL3702739 | 0.81 | MET (0.48) | KDRPDGFRAMETAXL | |
| SCHEMBL29487188 | 0.77 | PDGFRA (0.59) | KDRPDGFRAMETAXL | |
| SCHEMBL174159 | 0.77 | PDGFRA (0.59) | KDRPDGFRAMETAXL | |
| SCHEMBL371803 | 0.77 | MET (0.55) | KDRPDGFRAMETAXL | |
| SCHEMBL30713842 | 0.77 | MET (0.55) | KDRPDGFRAMETAXL | |
| SCHEMBL4483017 | 0.77 | MET (0.55) | KDRPDGFRAMETAXL | |
| SCHEMBL452389 | 0.76 | AURKB (0.55) | KDRPDGFRAMETAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621904-A2 | COMPOUNDS AS C-MET KINASE INHIBITORS | Advenchen Laboratories, LLC (US) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012034055-A2 | COMPOUNDS AS C-MET KINASE INHIBITORS | ADVENCHEN LABORATORIES, LLC (US) | 2012-03-15 | — | — | WO | disclosed |