Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 4/20 | 0.55 |
| ▸ | FLT1 | P17948 | 3/20 | 0.55 |
| ▸ | MET | P08581 | 10/20 | 0.53 |
| ▸ | AXL | P30530 | 9/20 | 0.53 |
| ▸ | KDR | P35968 | 7/20 | 0.53 |
| ▸ | FLT3 | P36888 | 3/20 | 0.53 |
| ▸ | KIT | P10721 | 3/20 | 0.53 |
| ▸ | MERTK | Q12866 | 3/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | LYN | P07948 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL469355 | 0.84 | AURKB (0.57) | AURKBFLT1METAXLKDR | |
| SCHEMBL452388 | 0.84 | PDGFRA (0.50) | AURKBFLT1METAXLKDR | |
| SCHEMBL469349 | 0.81 | AURKB (0.65) | AURKBFLT1METAXLKDR | |
| SCHEMBL469356 | 0.80 | AURKB (0.60) | AURKBFLT1METAXLKDR | |
| SCHEMBL469348 | 0.80 | AURKB (0.59) | AURKBFLT1METAXLKDR | |
| SCHEMBL469354 | 0.79 | AURKB (0.58) | AURKBFLT1METAXLKDR | |
| SCHEMBL5048227 | 0.78 | MET (0.57) | AURKBFLT1METAXLKDR | |
| SCHEMBL453312 | 0.78 | AXL (0.49) | METAXLKDR | |
| SCHEMBL469262 | 0.78 | AURKB (0.56) | AURKBFLT1METAXLKDR | |
| SCHEMBL453854 | 0.76 | KDR (0.46) | METAXLKDRPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621904-A2 | COMPOUNDS AS C-MET KINASE INHIBITORS | Advenchen Laboratories, LLC (US) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012034055-A2 | COMPOUNDS AS C-MET KINASE INHIBITORS | ADVENCHEN LABORATORIES, LLC (US) | 2012-03-15 | — | — | WO | disclosed |