Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 5/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.43 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4529413 | 0.89 | DHFR (0.40) | DHFRNLRP3TRIM58KDM4ELMNA | |
| SCHEMBL4532427 | 0.88 | DHFR (0.46) | DHFRNLRP3TRIM58KDM4ELMNA | |
| SCHEMBL4523825 | 0.85 | NLRP3 (0.46) | DHFRNLRP3TRIM58HRH4MAP4K4 | |
| SCHEMBL4528809 | 0.84 | DHFR (0.65) | DHFRNLRP3TRIM58HRH4MAP4K4 | |
| SCHEMBL4532712 | 0.82 | DHFR (0.61) | DHFRNLRP3TRIM58HRH4MAP4K4 | |
| SCHEMBL4529240 | 0.80 | PTPN1 (0.53) | DHFRNLRP3KDM4ELMNAHRH4 | |
| SCHEMBL4524948 | 0.79 | DHFR (0.48) | DHFRNLRP3KDM4ELMNAPTPN1 | |
| SCHEMBL4524783 | 0.79 | MAP4K4 (0.52) | DHFRNLRP3TRIM58HRH4MAP4K4 | |
| Trifluoroacetic Acid SCHEMBL4521203 | 0.79 | DHFR (0.43) | DHFRNLRP3TRIM58KDM4ELMNA | |
| SCHEMBL4355863 | 0.78 | CDK2 (0.40) | DHFRTRIM58KDM4ELMNACCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | BERTHEL STEVEN JOSEPH | 2009-04-23 | — | — | US | claimed |
| US-20060211715-A1 | Quinazoline protein tyrosine phosphatase inhibitors | BERTHEL STEVEN J | 2006-09-21 | — | — | US | claimed |
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | BERTHEL STEVEN JOSEPH | 2009-04-23 | — | — | US | disclosed |
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | BERTHEL STEVEN JOSEPH | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | PTPN5, PTPN1, PTPN7 | DHFR 2071/4885NLRP3 618/4885TRIM58 2337/4885 |
| US-20060211715-A1 | Quinazoline protein tyrosine phosphatase inhibitors | PTPN5, PTPN1, PTPN7 | DHFR 2071/4885NLRP3 618/4885TRIM58 2337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.