SCHEMBL4527628

SCHEMBL4527628

CC(OC(=O)Cl)c1cc2c(cc1[N+](=O)[O-])COO2

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.40
LMNA P02545 1/20 0.40
PDK1 Q15118 2/20 0.34
SRC P12931 1/20 0.34
MAPT P10636 2/20 0.32
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
MAP2K1 Q02750 1/20 0.30
KDM4E B2RXH2 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17257752 0.81 ALDH1A1 (0.34) ALDH1A1LMNASRCMAPTMEN1
SCHEMBL4527630 0.81 SRC (0.52) ALDH1A1LMNASRCMAPTMEN1
SCHEMBL3768323 0.81 SRC (0.52) ALDH1A1LMNASRCMAPTMEN1
SCHEMBL28954076 0.76 SRC (0.42) ALDH1A1LMNAPDK1SRCMAPT
SCHEMBL22658035 0.73 ALDH1A1 (0.34) ALDH1A1LMNASRC
SCHEMBL13347473 0.69 SRC (0.53) ALDH1A1LMNASRCMAPTMEN1
SCHEMBL28607638 0.69 SRC (0.53) ALDH1A1LMNASRCMAPTMEN1
SCHEMBL12050499 0.69 ALDH1A1 (0.60) ALDH1A1LMNASRCMAPTMEN1
SCHEMBL7598875 0.69 PDK1 (0.43) ALDH1A1LMNAPDK1MAPTMEN1
SCHEMBL29573208 0.68 ALDH1A1 (0.55) ALDH1A1PDK1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160194707-A1 3' BIASED DETECTION OF NUCLEIC ACIDS ARCTURUS BIOSCIENCE, INC. 2016-07-07 US disclosed
US-20140303038-A1 3' Biased Detection of Nucleic Acids Life Technologies Corporation (US) 2014-10-09 US disclosed
US-20090270271-A1 3' Biased Detection of Nucleic Acids MOLECULAR DEVICES, INC. 2009-10-29 US disclosed
EP-1633891-A2 3' BIASED DETECTION OF NUCLEIC ACIDS Arcturus Bioscience, Inc. (US) 2006-03-15 EP disclosed
US-20050014168-A1 Solid support comprised of nucleotide sequences complimentary to 3' prime end of preferential polynucleotides for use as tool in detection of mammary gland cell proliferative disorders; gene expression analysis and cancer diagnosis ARCTURUS BIOSCIENCE, INC. (US) 2005-01-20 US disclosed
WO-2005001135-A2 3’ BIASED DETECTION OF NUCLEIC ACIDS ARCTURUS BIOSCIENCE, INC. (US) 2005-01-06 WO disclosed