SCHEMBL4527630

SCHEMBL4527630

C[C@@H](OC(=O)Cl)c1cc2c(cc1[N+](=O)[O-])OCO2

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SRC P12931 1/20 0.52
ALDH1A1 P00352 14/20 0.49
LMNA P02545 2/20 0.49
MAPT P10636 8/20 0.47
L3MBTL1 Q9Y468 5/20 0.47
MEN1 O00255 4/20 0.47
KMT2A Q03164 4/20 0.47
POLB P06746 2/20 0.47
MCL1 Q07820 1/20 0.47
KDM4E B2RXH2 6/20 0.43
RAB9A P51151 1/20 0.43
HPGD P15428 2/20 0.42
ALOX12 P18054 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
TDP1 Q9NUW8 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3768323 1.00 SRC (0.52) SRCALDH1A1LMNAMAPTL3MBTL1
SCHEMBL28607638 0.88 SRC (0.53) SRCALDH1A1LMNAMAPTL3MBTL1
SCHEMBL12050499 0.88 ALDH1A1 (0.60) SRCALDH1A1LMNAMAPTL3MBTL1
SCHEMBL13347473 0.88 SRC (0.53) SRCALDH1A1LMNAMAPTL3MBTL1
SCHEMBL22927432 0.81 SRC (0.55) SRCALDH1A1LMNAMAPTL3MBTL1
SCHEMBL4527628 0.81 ALDH1A1 (0.40) SRCALDH1A1LMNAMAPTMEN1
SCHEMBL125665 0.81 SRC (0.51) SRCALDH1A1LMNAMAPTL3MBTL1
SCHEMBL12050506 0.81 SRC (0.49) SRCALDH1A1LMNAMAPTL3MBTL1
SCHEMBL3489697 0.80 TXNRD1 (0.50) SRCALDH1A1LMNAMAPTMEN1
SCHEMBL11986891 0.80 SRC (0.50) SRCALDH1A1LMNAMAPTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240033362-A1 LIPID COMPOSITION FOR THE DELIVERY OF THERAPEUTIC CARGOS NAT TECH & ENG SOLUTIONS SANDIA LLC (US) 2024-02-01 US disclosed
US-11554369-B2 Microfluidic package and method of making the same NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC (US) 2023-01-17 US disclosed
US-11433121-B1 Lipid composition for the delivery of therapeutic cargos NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC (US) 2022-09-06 US disclosed
US-10933027-B1 Expanded pore particles and delivery methods thereof NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC (US) 2021-03-02 US disclosed
US-20200316596-A1 MICROFLUIDIC PACKAGE AND METHOD OF MAKING THE SAME NAT TECH & ENG SOLUTIONS SANDIA LLC (US) 2020-10-08 US disclosed
US-10717079-B2 Microfluidic package and method of making the same NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC (US) 2020-07-21 US disclosed
US-20170216840-A1 MICROFLUIDIC PACKAGE AND METHOD OF MAKING THE SAME NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC 2017-08-03 US disclosed
US-20160194707-A1 3' BIASED DETECTION OF NUCLEIC ACIDS ARCTURUS BIOSCIENCE, INC. 2016-07-07 US disclosed
US-20140303038-A1 3' Biased Detection of Nucleic Acids Life Technologies Corporation (US) 2014-10-09 US disclosed
US-20090270271-A1 3' Biased Detection of Nucleic Acids MOLECULAR DEVICES, INC. 2009-10-29 US disclosed
US-20050014168-A1 Solid support comprised of nucleotide sequences complimentary to 3' prime end of preferential polynucleotides for use as tool in detection of mammary gland cell proliferative disorders; gene expression analysis and cancer diagnosis ARCTURUS BIOSCIENCE, INC. (US) 2005-01-20 US disclosed
US-20030013868-A1 C-3' protected monomeric nucleotides and synthesis of oligonucleotides on solid support LINDEN TECHNOLOGIES, INC., A DELAWARE CORPORATION 2003-01-16 US disclosed
US-20030009027-A1 C-3' protected monomeric nucleotides and synthesis of oligonucleotides on solid support LINDEN TECHNOLOGIES, INC., A DELAWARE CORPORATION 2003-01-09 US disclosed
US-6489466-B2 PRODUCING IMMOBILIZED OLIGONUCLEOTIDES ON A SUBSTRATE BY COVALENTLY ATTACHING A FIRST NUCLEOTIDE OR OLIGONUCLEOTIDE VIA A C-5' OXYGEN OF THE NUCLEOTIDE TO THE SUBSTRATE; C-3'OXYGEN PROTECTED WITH PHOTO- OR CHEMICAL-LABILE GROUPS LINDEN TECHNOLOGIES, INC. 2002-12-03 US disclosed
US-20010044530-A1 C-3' protected monomeric nucleotides and synthesis of oligonucleotides on solid support LINDEN TECHNOLOGIES, INC. 2001-11-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030013868-A1 C-3' protected monomeric nucleotides and synthesis of oligonucleotides on solid support RNGTT, BCDIN3D, NT5C3B SRC 3126/4885ALDH1A1 3128/4885LMNA 720/4885
US-10933027-B1 Expanded pore particles and delivery methods thereof NPC1L1, NPC1, NUP210 SRC 4256/4885ALDH1A1 4526/4885LMNA 214/4885
US-20010044530-A1 C-3' protected monomeric nucleotides and synthesis of oligonucleotides on solid support RNGTT, BCDIN3D, NT5C3B SRC 3126/4885ALDH1A1 3128/4885LMNA 720/4885
US-20030009027-A1 C-3' protected monomeric nucleotides and synthesis of oligonucleotides on solid support RNGTT, BCDIN3D, NT5C3B SRC 3126/4885ALDH1A1 3128/4885LMNA 720/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.