Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 5/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.39 |
| ▸ | BACE1 | P56817 | 4/20 | 0.39 |
| ▸ | CTSD | P07339 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4533532 | 0.92 | DHFR (0.41) | LCKKDRJAK3MAPK14DHFR | |
| Trifluoroacetic Acid SCHEMBL4517911 | 0.90 | CRHR1 (0.43) | MAPTDHFRCRHR1EGLN1NOS1 | |
| SCHEMBL4521420 | 0.90 | LCK (0.50) | LCKKDRJAK3MAPK14MAPT | |
| Trifluoroacetic Acid SCHEMBL4523782 | 0.87 | CYP2D6 (0.44) | LCKKDRJAK3MAPK14DHFR | |
| Trifluoroacetic Acid SCHEMBL4519819 | 0.82 | HRH4 (0.43) | DHFRCRHR1EGLN1 | |
| SCHEMBL4517691 | 0.81 | DHFR (0.49) | LCKKDRJAK3MAPK14DHFR | |
| Trifluoroacetic Acid SCHEMBL4517024 | 0.81 | APP (0.54) | LCKKDRJAK3MAPK14DHFR | |
| Trifluoroacetic Acid SCHEMBL4530564 | 0.80 | NLRP3 (0.49) | LCKKDRJAK3MAPK14DHFR | |
| SCHEMBL4531645 | 0.79 | HRH4 (0.50) | MAPTDHFRCRHR1EGLN1NOS3 | |
| Trifluoroacetic Acid SCHEMBL4527702 | 0.76 | CYP2D6 (0.51) | DHFREGLN1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812409-A1 | AMINOQUINAZOLINES COMPOUNDS | F. Hoffmann-Roche AG (CH) | 2007-08-01 | — | — | EP | claimed |
| WO-2006050843-A1 | AMINOQUINAZOLINES COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-18 | — | — | WO | claimed |
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | BERTHEL STEVEN JOSEPH | 2009-04-23 | — | — | US | disclosed |
| EP-1812409-A1 | AMINOQUINAZOLINES COMPOUNDS | F. Hoffmann-Roche AG (CH) | 2007-08-01 | — | — | EP | disclosed |
| US-20060211715-A1 | Quinazoline protein tyrosine phosphatase inhibitors | BERTHEL STEVEN J | 2006-09-21 | — | — | US | disclosed |
| WO-2006050843-A1 | AMINOQUINAZOLINES COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | PTPN5, PTPN1, PTPN7 | LCK 80/4885KDR 2310/4885JAK3 199/4885 |
| US-20060211715-A1 | Quinazoline protein tyrosine phosphatase inhibitors | PTPN5, PTPN1, PTPN7 | LCK 80/4885KDR 2310/4885JAK3 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.