Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4514539 | 0.92 | ALDH1A1 (0.43) | MCL1ALDH1A1HPGDKDM4EHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL4530559 | 0.91 | ALDH1A1 (0.42) | MCL1ALDH1A1HPGDKDM4EHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL4523754 | 0.88 | CNR1 (0.43) | MCL1ALDH1A1HPGDKDM4EHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL4531108 | 0.87 | ALDH1A1 (0.43) | MCL1ALDH1A1HPGDKDM4EHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL4520540 | 0.86 | TPSAB1 (0.41) | MCL1ALDH1A1HPGDKDM4EHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL4515642 | 0.86 | KDM4E (0.43) | MCL1ALDH1A1HPGDKDM4EHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL4529169 | 0.86 | KDM4E (0.41) | MCL1ALDH1A1HPGDKDM4EHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL4523799 | 0.86 | KDM4E (0.41) | MCL1ALDH1A1HPGDKDM4EHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL4515923 | 0.86 | MCL1 (0.44) | MCL1ALDH1A1KDM4EHSD17B10KMT2A | |
| Trifluoroacetic Acid SCHEMBL4521871 | 0.86 | KDM4E (0.40) | MCL1ALDH1A1HPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275555-A1 | Substituted indole ligands for the ORL-1 receptor | BRANE DISCOVERY S.R.L. (IT) | 2009-11-05 | — | — | US | claimed |
| US-20090275555-A1 | Substituted indole ligands for the ORL-1 receptor | BRANE DISCOVERY S.R.L. (IT) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275555-A1 | Substituted indole ligands for the ORL-1 receptor | OGFRL1, OPRL1, ORMDL3 | MCL1 1303/4885ALDH1A1 395/4885HPGD 3192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.