Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15498199 | 0.81 | CHRNB2 (0.73) | CHRNB2CHRNA4ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL16580896 | 0.80 | CHRNB2 (0.65) | CHRNB2CHRNA4ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL7099639 | 0.79 | CHRNB2 (0.63) | CHRNB2CHRNA4ALDH1A1KDM4ECHRNB4 | |
| SCHEMBL3442965 | 0.78 | CHRNB2 (0.66) | CHRNB2CHRNA4ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL14028449 | 0.78 | CHRNB2 (0.69) | CHRNB2CHRNA4ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL11180739 | 0.77 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3POLB | |
| SCHEMBL541821 | 0.77 | MEN1 (0.61) | CHRNB2CHRNA4ALDH1A1DRD2DRD4 | |
| SCHEMBL15272157 | 0.76 | HPGD (0.59) | ALDH1A1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL4523282 | 0.76 | POLB (0.64) | ALDH1A1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL3029851 | 0.76 | MEN1 (0.56) | CHRNB2CHRNA4ALDH1A1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036474-A1 | Quinazoline derivatives for use against cancer | PLE PATRICK | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036474-A1 | Quinazoline derivatives for use against cancer | AQP3, AQP1, F12 | CHRNB2 3994/4885CHRNA4 2220/4885ALDH1A1 2449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.