Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.36 |
| ▸ | MTOR | P42345 | 9/20 | 0.36 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4509837 | 0.99 | PIK3CA (0.37) | PRKCIITGB3ITGA2BPIK3CAMTOR | |
| Hydrochloric Acid SCHEMBL4518127 | 0.86 | RORC (0.41) | PRKCIPIK3CAMTORPIK3C2BCCNE2 | |
| SCHEMBL390467 | 0.84 | PRKCI (0.36) | PRKCIPIK3CAMTORPIK3C2BCCNE2 | |
| SCHEMBL390110 | 0.83 | PRKCI (0.43) | PRKCIPIK3CAMTORPIK3C2BCCNE2 | |
| Hydrochloric Acid SCHEMBL4526797 | 0.82 | PIK3CA (0.42) | PRKCIPIK3CAMTORPIK3C2BCCNE2 | |
| SCHEMBL390254 | 0.82 | PRKCI (0.40) | PRKCIPIK3CAMTORPIK3C2BCCNE2 | |
| SCHEMBL390178 | 0.82 | MPL (0.40) | PRKCIPIK3CAMTORPIK3C2BCCNE2 | |
| Hydrochloric Acid SCHEMBL4508182 | 0.82 | PRKCI (0.39) | PRKCIPIK3CAMTORPIK3C2BCCNE2 | |
| Hydrochloric Acid SCHEMBL4518145 | 0.82 | MPL (0.39) | PRKCIPIK3CAMTORPIK3C2BCCNE2 | |
| SCHEMBL4508184 | 0.81 | RAF1 (0.38) | PRKCIPIK3CAMTORPIK3C2BCCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557112-B2 | Aromatic-ring-fused pyrimidine derivative | ASTELLAS PHARMA INC. (JP) | 2009-07-07 | — | — | US | disclosed |
| US-20070249587-A1 | Aromatic-Ring-Fused Pyrimidine Derivative | ASTELLAS PHARMA INC. (JP) | 2007-10-25 | — | — | US | disclosed |
| EP-1806347-A1 | AROMATIC-RING-FUSED PYRIMIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2007-07-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249587-A1 | Aromatic-Ring-Fused Pyrimidine Derivative | GPR119, NOD1, IRS1 | PRKCI 2657/4885ITGB3 4788/4885ITGA2B 4786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.