SCHEMBL452967

SCHEMBL452967

Nc1nc2c(ncn2CC(=O)O)c(=S)[nH]1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.47
KDM4E B2RXH2 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
PNP P00491 6/20 0.46
TK1 P04183 2/20 0.46
BLM P54132 2/20 0.45
USP2 O75604 1/20 0.45
TSHR P16473 1/20 0.45
EDNRA P25101 1/20 0.45
HTR2A P28223 1/20 0.45
RECQL P46063 1/20 0.45
HBB P68871 1/20 0.45
HSD17B10 Q99714 1/20 0.45
MEN1 O00255 1/20 0.43
LMNA P02545 1/20 0.43
CYP3A4 P08684 1/20 0.43
NFKB1 P19838 1/20 0.43
VCP P55072 1/20 0.43
KMT2A Q03164 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL455494 0.84 PNP (0.64) ALDH1A1PNPTK1BLMUSP2
SCHEMBL16167797 0.78 GAA (0.61) ALDH1A1KDM4ETDP1PNPTK1
SCHEMBL11244716 0.76 PNP (0.73) ALDH1A1PNPTK1BLMUSP2
SCHEMBL1746164 0.75 TK1 (0.37) ALDH1A1PNPTK1BLMUSP2
SCHEMBL5930322 0.75 TK1 (0.52) ALDH1A1PNPTK1BLMUSP2
SCHEMBL7745038 0.74 HPRT1 (0.52) ALDH1A1KDM4EPNPBLMUSP2
SCHEMBL8302 0.74 XDH (0.39) ALDH1A1PNPTK1BLMUSP2
SCHEMBL1672138 0.74 CDK1 (0.62) ALDH1A1KDM4ETDP1LMNACSNK2A2
SCHEMBL30052313 0.74 CDK1 (0.62) ALDH1A1KDM4ETDP1LMNACSNK2A2
SCHEMBL469372 0.73 KDM4E (0.48) ALDH1A1KDM4ETDP1PNPTK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200292535-A1 METHOD FOR EVALUATION OF TARGET IN HISTOLOGICAL SAMPLE DAKO DENMARK A/S (DK) 2020-09-17 US disclosed
US-10648970-B2 Method for evaluation of target in histological sample AGILENT TECHNOLOGIES, INC. (US) 2020-05-12 US disclosed
EP-2646795-B1 METHODS FOR ANALYZING IMAGES OF SPECIMENS PROCESSED BY A PROGRAMMABLE QUANTITATIVE ASSAY DAKO DENMARK AS (DK) 2019-02-20 EP disclosed
US-10180426-B2 Quantification of single target molecules in histological samples DAKO DENMARK A/S (DK) 2019-01-15 US disclosed
US-9970874-B2 Methods and systems for analyzing images of specimens processed by a programmable quantitative assay DAKO DENMARK A/S (DK) 2018-05-15 US disclosed
US-9958449-B2 Method for enzyme-mediated signal amplification DAKO DENMARK A/S (DK) 2018-05-01 US disclosed
EP-2699691-B1 NEW METHOD FOR ENZYME-MEDIATED SIGNAL AMPLIFICATION DAKO DENMARK AS (DK) 2017-10-18 EP disclosed
US-9671400-B2 Conjugate molecules DAKO DENMARK A/S (DK) 2017-06-06 US disclosed
CN-103597089-B method for enzyme-mediated signal amplification 丹麦达科有限公司 2017-04-12 CN disclosed
CN-104714007-B Immunochemical detection of single target entities 丹麦达科有限公司 2017-04-12 CN disclosed
WO-2012062318-A1 QUANTIFICATION OF SINGLE TARGET MOLECULES IN HISTOLOGICAL SAMPLES DAKO DENMARK A/S (DK) 2012-05-18 WO disclosed
US-20120065364-A2 PEPTIDE NUCLEIC ACID MONOMERS AND OLIGOMERS NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2012-03-15 US disclosed
CN-102325895-A Conjugate molecules DAKO DENMARK AS 2012-01-18 CN disclosed
US-20110245458-A1 PEPTIDE NUCLEIC ACID MONOMERS AND OLIGOMERS NANYANG TECHONOLOGICAL UNIVERSITY (SG) 2011-10-06 US disclosed
WO-2011047680-A1 IMMUNOCHEMICAL DETECTION OF SINGLE TARGET ENTITIES DAKO DENMARK A/S (DK) 2011-04-28 WO disclosed
US-20100240085-A1 CONJUGATE MOLECULES DAKO DENMARK APS (DK) 2010-09-23 US disclosed
US-20100240047-A1 METHODS AND COMPOUNDS FOR DETECTION OF MOLECULAR TARGETS DAKO DENMARK APS (DK) 2010-09-23 US disclosed
WO-2010094284-A1 METHODS AND COMPOUNDS FOR DETECTION OF MOLECULAR TARGETS DAKO DENMARK A/S (DK) 2010-08-26 WO disclosed
WO-2010094283-A1 CONJUGATE MOLECULES DAKO DENMARK A/S (DK) 2010-08-26 WO disclosed
WO-2010027326-A1 PEPTIDE NUCLEIC ACID MONOMERS AND OLIGOMERS NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2010-03-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120065364-A2 PEPTIDE NUCLEIC ACID MONOMERS AND OLIGOMERS SIN3A, POLR2H, CYTH3 ALDH1A1 4860/4885KDM4E 4577/4885TDP1 3869/4885
US-20110245458-A1 PEPTIDE NUCLEIC ACID MONOMERS AND OLIGOMERS SIN3A, POLR2H, CYTH3 ALDH1A1 4860/4885KDM4E 4577/4885TDP1 3869/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.