Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DKK1 | O94907 | 4/20 | 0.70 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4529870 | 1.00 | DKK1 (0.70) | DKK1DPP4PDE10AHCRTR1HCRTR2 | |
| SCHEMBL4529867 | 1.00 | DKK1 (0.70) | DKK1DPP4PDE10AHCRTR1HCRTR2 | |
| SCHEMBL3643372 | 0.84 | DKK1 (0.78) | DKK1DPP4PDE10AHCRTR1HCRTR2 | |
| SCHEMBL3648934 | 0.82 | DKK1 (0.86) | DKK1DPP4PIK3CA | |
| SCHEMBL3652626 | 0.82 | DKK1 (0.86) | DKK1DPP4PIK3CA | |
| SCHEMBL3648931 | 0.82 | DKK1 (0.86) | DKK1DPP4PIK3CA | |
| SCHEMBL3644036 | 0.82 | DKK1 (1.00) | DKK1DPP4PIK3CAGSK3B | |
| SCHEMBL3644447 | 0.81 | DKK1 (0.68) | DKK1DPP4PDE10AHCRTR1HCRTR2 | |
| SCHEMBL3649779 | 0.81 | DKK1 (0.64) | DKK1DPP4PDE10AHCRTR1HCRTR2 | |
| SCHEMBL4535227 | 0.81 | DKK1 (0.61) | DKK1PDE10AHCRTR1HCRTR2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054392-A1 | NAPHTHYLPYRIMIDINE, NAPHTHYLPYRAZINE AND NAPHTHYLPYRIDAZINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2009-02-26 | — | — | US | claimed |
| US-20090054392-A1 | NAPHTHYLPYRIMIDINE, NAPHTHYLPYRAZINE AND NAPHTHYLPYRIDAZINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054392-A1 | NAPHTHYLPYRIMIDINE, NAPHTHYLPYRAZINE AND NAPHTHYLPYRIDAZINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WNT1, CTNNB1, WNT3A | DKK1 9/4885DPP4 1128/4885PDE10A 1605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.