Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 7/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4530182 | 1.00 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2TP53THRB | |
| SCHEMBL4526665 | 0.85 | GAA (0.39) | PRMT5WDR77NAMPTKMT2AMAPT | |
| SCHEMBL4526667 | 0.85 | GAA (0.39) | PRMT5WDR77NAMPTKMT2AMAPT | |
| SCHEMBL4523482 | 0.84 | HRH3 (0.46) | PRMT5WDR77KMT2AMEN1 | |
| SCHEMBL4523488 | 0.84 | HRH3 (0.46) | PRMT5WDR77KMT2AMEN1 | |
| SCHEMBL4537456 | 0.82 | HRH3 (0.41) | TP53PRMT5WDR77NAMPTKMT2A | |
| SCHEMBL4537453 | 0.82 | HRH3 (0.41) | TP53PRMT5WDR77NAMPTKMT2A | |
| SCHEMBL4528343 | 0.81 | CTSS (0.42) | PRMT5WDR77KMT2AATMMEN1 | |
| SCHEMBL4528342 | 0.81 | CTSS (0.42) | PRMT5WDR77KMT2AATMMEN1 | |
| SCHEMBL4522695 | 0.79 | HRH3 (0.41) | PRMT5WDR77KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099157-A1 | TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099157-A1 | TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S | CTSS, CTSE, CTSK | NPC1 653/4885RAB9A 1129/4885SMN1; SMN2 4554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.