Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537224 | 0.97 | P2RX7 (0.43) | P2RX7POLBDRD2DRD4 | |
| SCHEMBL4542459 | 0.88 | P2RX7 (0.42) | P2RX7 | |
| SCHEMBL8069525 | 0.88 | EPHX2 (0.45) | POLB | |
| SCHEMBL4541718 | 0.87 | EPHX1 (0.46) | POLB | |
| SCHEMBL8067471 | 0.87 | EPHX1 (0.46) | POLB | |
| SCHEMBL4534371 | 0.87 | DRD2 (0.41) | P2RX7DRD2DRD4 | |
| SCHEMBL4542906 | 0.87 | TP53 (0.43) | P2RX7POLBDRD2DRD4 | |
| SCHEMBL8049794 | 0.87 | POLB (0.39) | P2RX7POLB | |
| SCHEMBL4538787 | 0.86 | PSEN1 (0.51) | POLBDRD2DRD4 | |
| SCHEMBL4542333 | 0.86 | PSEN1 (0.51) | POLBDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |