Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542906 | 0.91 | TP53 (0.43) | DRD2DRD4PSEN1PSEN2APH1B | |
| SCHEMBL4537224 | 0.90 | P2RX7 (0.43) | DRD2DRD4PSEN1PSEN2APH1B | |
| SCHEMBL4542326 | 0.88 | RAB9A (0.47) | DRD2ALDH1A1 | |
| SCHEMBL4530293 | 0.87 | P2RX7 (0.44) | DRD2DRD4P2RX7 | |
| SCHEMBL4535933 | 0.85 | PSEN1 (0.56) | DRD2DRD4ALDH1A1PSEN1PSEN2 | |
| SCHEMBL4537060 | 0.85 | ALDH1A1 (0.43) | DRD2ALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL4538141 | 0.84 | BDKRB1 (0.46) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4531364 | 0.84 | HSD11B1 (0.44) | ALDH1A1P2RX7 | |
| SCHEMBL4541043 | 0.84 | ITGB1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4537759 | 0.83 | RAB9A (0.45) | PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |