Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537228 | 0.97 | POLB (0.41) | POLBRAB9ADRD2 | |
| SCHEMBL4542462 | 0.88 | RAB9A (0.46) | RAB9A | |
| SCHEMBL4541720 | 0.86 | POLB (0.43) | POLBRAB9A | |
| SCHEMBL4534376 | 0.86 | PSEN1 (0.40) | RAB9ADRD2 | |
| SCHEMBL4542909 | 0.86 | TP53 (0.47) | POLBRAB9A | |
| SCHEMBL4542334 | 0.85 | PSEN1 (0.53) | POLBRAB9A | |
| SCHEMBL4538792 | 0.85 | PSEN1 (0.53) | POLBRAB9A | |
| SCHEMBL4538974 | 0.85 | CYP19A1 (0.39) | RAB9A | |
| SCHEMBL4531367 | 0.85 | RAB9A (0.43) | RAB9A | |
| SCHEMBL4537039 | 0.85 | EPHX2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |