Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | USP5 | P45974 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537385 | 0.95 | KMT2A (0.43) | EPHX2KMT2AMEN1USP5KDM4E | |
| SCHEMBL4537314 | 0.91 | POLB (0.44) | EPHX2KMT2AMEN1HTTTRPV4 | |
| SCHEMBL4542825 | 0.87 | HDAC3 (0.53) | EPHX2KMT2AUSP5LMNAALDH1A1 | |
| SCHEMBL4541778 | 0.86 | LMNA (0.58) | KMT2AMEN1USP5LMNASMN1; SMN2 | |
| SCHEMBL4530295 | 0.85 | POLB (0.44) | — | |
| SCHEMBL4542446 | 0.84 | SMN1; SMN2 (0.53) | KMT2AMEN1LMNASMN1; SMN2KDM4E | |
| SCHEMBL4537228 | 0.84 | POLB (0.41) | KMT2A | |
| SCHEMBL4539756 | 0.82 | HDAC3 (0.50) | EPHX2KMT2AALDH1A1 | |
| SCHEMBL4535939 | 0.81 | USP30 (0.48) | EPHX2KMT2AMEN1SMN1; SMN2TRPV4 | |
| SCHEMBL8060983 | 0.80 | P2RX7 (0.47) | EPHX2KMT2AMEN1KDM4ETRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |