Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542462 | 0.97 | RAB9A (0.46) | RAB9AHSD11B1 | |
| SCHEMBL4537228 | 0.88 | POLB (0.41) | RAB9AKMT2A | |
| SCHEMBL4533525 | 0.88 | KMT2A (0.48) | RAB9AKMT2AALDH1A1MCOLN3MEN1 | |
| SCHEMBL4539752 | 0.87 | HSD11B1 (0.56) | RAB9AHSD11B1 | |
| SCHEMBL4531594 | 0.87 | TDP1 (0.42) | RAB9AOPRM1OPRK1HSD11B1 | |
| SCHEMBL4534767 | 0.86 | FAAH (0.41) | OPRM1OPRK1HSD11B1KMT2AALDH1A1 | |
| SCHEMBL4537339 | 0.85 | ATM (0.49) | RAB9AOPRM1OPRK1KMT2AALDH1A1 | |
| SCHEMBL4537566 | 0.85 | RAB9A (0.57) | RAB9AALDH1A1 | |
| SCHEMBL4530295 | 0.85 | POLB (0.44) | RAB9A | |
| SCHEMBL4537325 | 0.84 | MEN1 (0.51) | RAB9AKMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |