Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | NQO1 | P15559 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GRK6 | P43250 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9244853 | 0.82 | NQO1 (0.36) | NQO1TDP1TSHR | |
| SCHEMBL10334834 | 0.82 | ALDH1A1 (0.38) | ALDH1A1NQO1L3MBTL1KDM4EMAPT | |
| SCHEMBL285513 | 0.80 | TSHR (0.38) | ALDH1A1NQO1L3MBTL1KDM4EMAPT | |
| SCHEMBL11779722 | 0.78 | ALDH1A1 (0.34) | ALDH1A1NQO1L3MBTL1KDM4EMAPT | |
| SCHEMBL285182 | 0.73 | ALDH1A1 (0.45) | ALDH1A1NQO1L3MBTL1KDM4EMAPT | |
| SCHEMBL10345470 | 0.73 | NCOA1 (0.36) | ALDH1A1NQO1KDM4EMAPTMAPK1 | |
| SCHEMBL8007834 | 0.72 | SMN1; SMN2 (0.43) | ALDH1A1NQO1L3MBTL1KDM4EMAPT | |
| SCHEMBL2456321 | 0.69 | NQO1 (0.36) | ALDH1A1NQO1MAPTHTTSMN1; SMN2 | |
| SCHEMBL12750190 | 0.69 | L3MBTL1 (0.56) | ALDH1A1NQO1L3MBTL1KDM4EMAPT | |
| SCHEMBL9674003 | 0.69 | TSHR (0.40) | ALDH1A1L3MBTL1KDM4EMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306122-A1 | SUBSTITUTED TETRAHYDROPYRROLOQUINOLINE DERIVATIVES AS KINASE MODULATORS, ESPECIALLY OF TYROSINE AND RAF KINASES | MERCK PATENT GMBH (DE) | 2009-12-10 | — | — | US | claimed |
| EP-1856116-A1 | SUBSTITUTED TETRAHYDROPYRROLOQUINOLINE DERIVATIVES AS KINASE MODULATORS, ESPECIALLY TYROSINE KINASE AND RAF KINASE MODULATORS | Merck Patent GmbH (DE) | 2007-11-21 | — | — | EP | claimed |
| WO-2006094600-A1 | SUBSTITUTED TETRAHYDROPYRROLOQUINOLINE DERIVATIVES AS KINASE MODULATORS, ESPECIALLY TYROSINE KINASE AND RAF KINASE MODULATORS | MERCK PATENT GMBH (DE) | 2006-09-14 | — | — | WO | claimed |
| EP-1189891-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION Bioscience AG (DE) | 2002-03-27 | — | — | EP | claimed |
| US-6362342-B1 | BIOSYNTHESIS; DRUG LIBRARIES | LION BIOSCIENCE AG (DE) | 2002-03-26 | — | — | US | claimed |
| WO-2001000594-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-01-04 | — | — | WO | claimed |
| US-20090306122-A1 | SUBSTITUTED TETRAHYDROPYRROLOQUINOLINE DERIVATIVES AS KINASE MODULATORS, ESPECIALLY OF TYROSINE AND RAF KINASES | MERCK PATENT GMBH (DE) | 2009-12-10 | — | — | US | disclosed |
| EP-1856116-A1 | SUBSTITUTED TETRAHYDROPYRROLOQUINOLINE DERIVATIVES AS KINASE MODULATORS, ESPECIALLY TYROSINE KINASE AND RAF KINASE MODULATORS | Merck Patent GmbH (DE) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006094600-A1 | SUBSTITUTED TETRAHYDROPYRROLOQUINOLINE DERIVATIVES AS KINASE MODULATORS, ESPECIALLY TYROSINE KINASE AND RAF KINASE MODULATORS | MERCK PATENT GMBH (DE) | 2006-09-14 | — | — | WO | disclosed |
| US-6362342-B1 | BIOSYNTHESIS; DRUG LIBRARIES | LION BIOSCIENCE AG (DE) | 2002-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306122-A1 | SUBSTITUTED TETRAHYDROPYRROLOQUINOLINE DERIVATIVES AS KINASE MODULATORS, ESPECIALLY OF TYROSINE AND RAF KINASES | TIE1, FER, RET | ALDH1A1 3078/4885NQO1 1552/4885L3MBTL1 1908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.