SCHEMBL4533458

SCHEMBL4533458

Clc1ccc2[nH][c]c(Cl)c2c1Cl

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
AR P10275 2/20 0.36
GRIN2D O15399 1/20 0.34
GRIN3B O60391 1/20 0.34
GRIN1 Q05586 1/20 0.34
GRIN2A Q12879 1/20 0.34
GRIN2B Q13224 1/20 0.34
GRIN2C Q14957 1/20 0.34
GRIN3A Q8TCU5 1/20 0.34
CYP3A4 P08684 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2379988 0.74 GPR84 (0.41) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL450896 0.67 PDPK1 (0.39)
SCHEMBL11605727 0.61 GAA (0.41) ARGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL11232989 0.61 GPR84 (0.41) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL10832750 0.60 MEN1 (0.30)
SCHEMBL29368277 0.59 CYP3A4 (0.62) CYP3A4MAPK1
SCHEMBL348089 0.59 CYP3A4 (0.62) CYP3A4MAPK1
SCHEMBL1639050 0.59 ALDH1A1 (0.40) CYP3A4
SCHEMBL206305 0.58 KDM4E (0.39) MAPK1
SCHEMBL7459887 0.58 GPR84 (0.39) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8318452-B2 Solid culture medium for the detection and/or the species discrimination of glycopeptide-resistant enterococci RAMBACH ALAIN (FR) 2012-11-27 US claimed
US-20090280524-A1 SOLID CULTURE MEDIUM FOR THE DETECTION AND/OR THE SPECIES DISCRIMINATION OF GLYCOPEPTIDE-RESISTANT ENTEROCOCCI RAMBACH ALAIN 2009-11-12 US claimed
US-20140342385-A1 MEDIUM AND METHOD FOR DETECTING PATHOGENIC YERSINIA ENTEROCOLITICA BACTERIA RAMBACH ALAIN (FR) 2014-11-20 US disclosed
US-8318452-B2 Solid culture medium for the detection and/or the species discrimination of glycopeptide-resistant enterococci RAMBACH ALAIN (FR) 2012-11-27 US disclosed
US-20090280524-A1 SOLID CULTURE MEDIUM FOR THE DETECTION AND/OR THE SPECIES DISCRIMINATION OF GLYCOPEPTIDE-RESISTANT ENTEROCOCCI RAMBACH ALAIN 2009-11-12 US disclosed