Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.37 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7459887 | 0.79 | GPR84 (0.39) | GPR84GAAPSMB8ERCC5FEN1 | |
| SCHEMBL4694663 | 0.79 | GAA (0.39) | GPR84GAAPSMB8ERCC5FEN1 | |
| SCHEMBL450896 | 0.79 | PDPK1 (0.39) | PSMB8FEN1NOS1CYP2A6GPR17 | |
| SCHEMBL6009055 | 0.71 | ERCC5 (0.53) | GPR84GAAPSMB8ERCC5FEN1 | |
| SCHEMBL31619545 | 0.71 | ERCC5 (0.53) | GPR84GAAPSMB8ERCC5FEN1 | |
| SCHEMBL10794636 | 0.69 | ALDH1A1 (0.38) | GAAERCC5FEN1NR4A2MAP2K4 | |
| SCHEMBL1639050 | 0.68 | ALDH1A1 (0.40) | GPR84GAANOS1CYP1A2CYP2A6 | |
| SCHEMBL20276479 | 0.67 | ERCC5 (0.50) | GPR84GAAPSMB8ERCC5FEN1 | |
| SCHEMBL15826494 | 0.64 | GPR84 (0.64) | GPR84GAAPSMB8ERCC5FEN1 | |
| SCHEMBL29764387 | 0.64 | GPR84 (0.64) | GPR84GAAPSMB8ERCC5FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022005-B2 | Halogen substituted heterocyclic heteroatom containing ligands-alumoxane activation of metallocenes | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2011-09-20 | — | — | US | disclosed |
| US-20090124486-A1 | HALOGEN SUBSTITUTED HETEROCYCLIC HETEROATOM CONTAINING LIGANDS-ALUMOXANE ACTIVATION OF METALLOCENES | EXXONMOBIL CHEMICAL PATENTS INC. | 2009-05-14 | — | — | US | disclosed |
| EP-1341766-B1 | IMIDAZOLONE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES | HOFFMANN LA ROCHE (CH) | 2005-10-26 | — | — | EP | disclosed |
| EP-1341766-A1 | IMIDAZOLONE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-09-10 | — | — | EP | disclosed |
| US-6518293-B2 | Inhibitors of the human immunodeficiency virus reverse transcriptase enzyme which is involved in viral replication. | HOFFMANN-LA ROCHE INC. | 2003-02-11 | — | — | US | disclosed |
| US-20020107272-A1 | Anti-HIV imidazolone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-08 | — | — | US | disclosed |
| WO-2002042279-A1 | IMIDAZOLONE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020107272-A1 | Anti-HIV imidazolone derivatives | EIF2AK2, IMPDH1, POLR2E | GPR84 3532/4885GAA 369/4885PSMB8 3094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.