Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5875528 | 0.74 | ALDH1A1 (0.42) | CSNK2A1CYP2C19MAPTCYP3A4TSHR | |
| SCHEMBL4523487 | 0.73 | KDM4E (0.40) | CYP2C19MAPTHSD17B10POLBCYP3A4 | |
| SCHEMBL3334158 | 0.71 | KIF11 (0.35) | MAPT | |
| SCHEMBL3334153 | 0.71 | KIF11 (0.35) | MAPT | |
| SCHEMBL2678850 | 0.70 | KDR (0.53) | CDK2KDRCSNK2A1CDK5CYP3A4 | |
| SCHEMBL13301117 | 0.70 | HDAC1 (0.34) | MAPTALDH1A1HPGDIKBKB | |
| SCHEMBL4019091 | 0.65 | HCAR2 (0.55) | CSNK2A1MAPTPOLBTSHRKDM4E | |
| SCHEMBL5875785 | 0.65 | HSD17B1 (0.39) | CHEK2CSF1RCDK2CSNK2A1CDK5 | |
| SCHEMBL3001292 | 0.64 | F2 (0.41) | CHEK1AURKADAPK3PIM1FGFR1 | |
| SCHEMBL5875616 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054445-A1 | Amide Substituted Quinolines | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | US | claimed |
| EP-1981882-A1 | AMIDE SUBSTITUTED QUINOLINES | AstraZeneca AB (SE) | 2008-10-22 | — | — | EP | claimed |
| WO-2007086799-A1 | AMIDE SUBSTITUTED QUINOLINES | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | claimed |
| US-20090054445-A1 | Amide Substituted Quinolines | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | US | disclosed |
| EP-1981882-A1 | AMIDE SUBSTITUTED QUINOLINES | AstraZeneca AB (SE) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007086799-A1 | AMIDE SUBSTITUTED QUINOLINES | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054445-A1 | Amide Substituted Quinolines | RECQL, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-0 | CHEK2 1821/4885PLK4 1254/4885CHEK1 2264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.