Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 9/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4533844 | 1.00 | HRH3 (0.38) | HRH3KMT2AMEN1CTSSABCB1 | |
| SCHEMBL4522695 | 0.90 | HRH3 (0.41) | HRH3KMT2AMEN1CTSSABCB1 | |
| SCHEMBL4522700 | 0.90 | HRH3 (0.41) | HRH3KMT2AMEN1CTSSABCB1 | |
| SCHEMBL4523488 | 0.85 | HRH3 (0.46) | HRH3KMT2AMEN1CTSS | |
| SCHEMBL4523482 | 0.85 | HRH3 (0.46) | HRH3KMT2AMEN1CTSS | |
| SCHEMBL4528343 | 0.84 | CTSS (0.42) | KMT2AMEN1CTSSATMPOLB | |
| SCHEMBL4528342 | 0.84 | CTSS (0.42) | KMT2AMEN1CTSSATMPOLB | |
| SCHEMBL4537453 | 0.83 | HRH3 (0.41) | HRH3KMT2AMEN1 | |
| SCHEMBL4537456 | 0.83 | HRH3 (0.41) | HRH3KMT2AMEN1 | |
| SCHEMBL4531585 | 0.79 | CTSS (0.38) | KMT2AMEN1CTSSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099157-A1 | TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099157-A1 | TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S | CTSS, CTSE, CTSK | HRH3 589/4885KMT2A 4175/4885MEN1 4868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.