Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 13/20 | 0.41 |
| ▸ | THRA | P10827 | 12/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4569628 | 0.90 | THRB (0.41) | THRBTHRAARACLYGAA | |
| SCHEMBL5116865 | 0.89 | THRA (0.47) | THRBTHRAARACLY | |
| SCHEMBL5106635 | 0.86 | THRA (0.38) | THRBTHRAARGAALMNA | |
| SCHEMBL5109944 | 0.85 | PPARD (0.44) | THRBTHRAARACLY | |
| SCHEMBL4355861 | 0.85 | THRB (0.44) | THRBTHRAGAAMAPT | |
| SCHEMBL4933734 | 0.84 | THRB (0.45) | THRBTHRA | |
| SCHEMBL5111291 | 0.84 | FFAR1 (0.37) | THRBARGAALMNAMAPT | |
| SCHEMBL4930990 | 0.84 | THRB (0.42) | THRBTHRA | |
| SCHEMBL4940742 | 0.83 | THRB (0.40) | THRBTHRA | |
| SCHEMBL4932176 | 0.83 | THRB (0.41) | THRBTHRAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | claimed |