Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 8/20 | 0.41 |
| ▸ | THRA | P10827 | 7/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4534757 | 0.90 | THRB (0.41) | THRBTHRAACLYARHPGD | |
| SCHEMBL5104431 | 0.89 | THRA (0.47) | THRBTHRAACLYARGRIN1 | |
| SCHEMBL4933734 | 0.85 | THRB (0.45) | THRBTHRA | |
| SCHEMBL5119963 | 0.85 | GRIN1 (0.41) | THRBTHRANPC1ARHPGD | |
| SCHEMBL5109829 | 0.84 | PPARD (0.44) | THRBTHRAACLYSMN1; SMN2PTGDR2 | |
| SCHEMBL5117669 | 0.84 | FFAR1 (0.37) | NPC1ARHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL4355861 | 0.83 | THRB (0.44) | THRBTHRAGAAMAPT | |
| SCHEMBL5109969 | 0.83 | THRB (0.43) | THRBTHRAHPGDSMN1; SMN2 | |
| SCHEMBL4930990 | 0.82 | THRB (0.42) | THRBTHRA | |
| SCHEMBL4932176 | 0.81 | THRB (0.41) | THRBTHRAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | claimed |