Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA3 | O75311 | 1/20 | 0.41 |
| ▸ | GLRB | P48167 | 1/20 | 0.41 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4126173 | 0.82 | GLRA3 (0.57) | GLRA3GLRBTNFRSF1ATSHRTDP1 | |
| SCHEMBL3579165 | 0.81 | TNFRSF1A (0.51) | TNFRSF1ATSHRTDP1ALDH1A1APOBEC3A | |
| SCHEMBL16148683 | 0.75 | NR1H4 (0.36) | GLRA3GLRBTNFRSF1ATSHRTDP1 | |
| SCHEMBL9577000 | 0.74 | PTPN1 (0.41) | TSHRTDP1ALDH1A1APOBEC3AHTT | |
| SCHEMBL6155461 | 0.72 | ALDH1A1 (0.50) | TSHRALDH1A1APOBEC3AHTTAPOBEC3G | |
| SCHEMBL29462682 | 0.72 | PTGS2 (0.44) | GLRA3GLRBTNFRSF1ATSHRTDP1 | |
| SCHEMBL17378865 | 0.71 | CFTR (0.40) | TNFRSF1AALDH1A1POLBHPGDKDM4E | |
| SCHEMBL3637333 | 0.71 | TNFRSF1A (0.56) | GLRA3GLRBTNFRSF1ACA1CA2 | |
| SCHEMBL2772941 | 0.71 | TNFRSF1A (0.53) | TNFRSF1ATSHRTDP1ALDH1A1CA1 | |
| SCHEMBL14988234 | 0.69 | GLRA3 (0.41) | GLRA3GLRBTDP1ALDH1A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270470-A1 | Compounds I | ASTRAZENECA AB (SE) | 2009-10-29 | — | — | US | claimed |
| EP-1881950-A1 | NEW COMPOUNDS I | AstraZeneca AB (SE) | 2008-01-30 | — | — | EP | claimed |
| WO-2006121391-A1 | NEW COMPOUNDS I | ASTRAZENECA AB (SE) | 2006-11-16 | — | — | WO | claimed |
| US-20090270470-A1 | Compounds I | ASTRAZENECA AB (SE) | 2009-10-29 | — | — | US | disclosed |
| EP-1881950-A1 | NEW COMPOUNDS I | AstraZeneca AB (SE) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006121391-A1 | NEW COMPOUNDS I | ASTRAZENECA AB (SE) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270470-A1 | Compounds I | F12, F11, F5 | GLRA3 2331/4885GLRB 2118/4885TNFRSF1A 4246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.