Desethylamiodarone

Desethylamiodarone

SCHEMBL4535165

CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCNCC)c(I)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 2/20 1.00
SIRT3 Q9NTG7 9/20 0.80
KDM5A P29375 7/20 0.78
KDM4A O75164 3/20 0.78
ING2 Q9H160 1/20 0.78
KDM7A Q6ZMT4 2/20 0.74
THRA P10827 2/20 0.74
THRB P10828 2/20 0.74
ALDH1A1 P00352 2/20 0.74
TP53 P04637 2/20 0.74
CYP3A4 P08684 2/20 0.74
SMN1; SMN2 Q16637 2/20 0.74
TDP1 Q9NUW8 2/20 0.74
MLNR O43193 1/20 0.74
CACNA1F O60840 1/20 0.74
PHF2 O75151 1/20 0.74
ABCB11 O95342 1/20 0.74
NR3C1 P04150 1/20 0.74
ERBB2 P04626 1/20 0.74
CYP1A2 P05177 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Desethylamiodarone SCHEMBL10680807 0.99 ABCB1 (0.98) ABCB1SIRT3KDM5AKDM4AING2
Desethylamiodarone SCHEMBL15618727 0.98 ABCB1 (0.96) ABCB1SIRT3KDM5AKDM4AING2
Desethylamiodarone SCHEMBL10673876 0.97 ABCB1 (0.95) ABCB1SIRT3KDM5AKDM4AING2
SCHEMBL23815659 0.95 ABCB1 (0.90) ABCB1SIRT3KDM5AKDM4AING2
SCHEMBL9094309 0.94 ABCB1 (0.89) ABCB1SIRT3KDM5AKDM4AING2
SCHEMBL7860433 0.92 ABCB1 (0.85) ABCB1SIRT3KDM5AKDM4AING2
Diethylamine SCHEMBL8994701 0.90 ABCB1 (0.82) ABCB1SIRT3KDM5AKDM4AING2
SCHEMBL25873319 0.90 KDM5A (0.86) ABCB1SIRT3KDM5AKDM4AING2
SCHEMBL18914365 0.90 ABCB1 (0.81) ABCB1SIRT3KDM5AKDM4AING2
SCHEMBL19895690 0.89 KDM5A (0.85) ABCB1SIRT3KDM5AKDM4AING2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 258 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260130113-A1 PIEZOELECTRIC FILMS INCLUDING IONIC LIQUIDS AND METHODS OF MAKING PIEZOELECTRIC FILMS INCLUDING IONIC LIQUIDS E INK CORP (US) 2026-05-07 US claimed
EP-4724062-A2 COMPOSITIONS AND METHODS FOR INCREASING EXPOSURE OF R(-)-MDA EmpathBio, Inc. (US) 2026-04-15 EP claimed
CN-120138218-A LMTIA primer probe combination for detecting rice source components in food and application thereof 许昌学院 2025-06-13 CN claimed
EP-4532607-A1 REACTIVE GEL MATERIAL FOR SUSTAINED WATER-BASED REACTIONS Everbond Interface Technologies, Inc. (CA) 2025-04-09 EP claimed
EP-4530636-A1 A METHOD AND SYSTEM FOR MONITORING A PANEL OF ANTIARRHYTHMIC DRUGS IN BLOOD Labexperts SP. Z O.O. (PL) 2025-04-02 EP claimed
CN-115639301-B Method for detecting amiodarone and desethyl amiodarone in blood plasma 北京豪思生物科技股份有限公司 2025-02-18 CN claimed
EP-4487666-A1 PIEZOELECTRIC FILM INCLUDING IONIC LIQUID AND ELECTROPHORETIC DISPLAY FILM INCLUDING THE PIEZOELECTRIC FILM E Ink Corporation (US) 2025-01-08 EP claimed
WO-2024254505-A2 COMPOSITIONS AND METHODS FOR INCREASING EXPOSURE OF R(-)-MDA ATAI Life Sciences AG (DE) 2024-12-12 WO claimed
CN-118715890-A Piezoelectric film comprising ionic liquid and electrophoretic display film comprising the same 伊英克公司 2024-09-27 CN claimed
US-20240279301-A1 METHODS AND COMPOSITIONS XAP THERAPEUTICS LIMITED (GB) 2024-08-22 US claimed
EP-4355858-A1 METHODS AND COMPOSITIONS Xap Therapeutics Limited (GB) 2024-04-24 EP claimed
CN-117765411-A Satellite remote sensing image fire point segmentation method and system based on deep learning 南京信息工程大学 2024-03-26 CN claimed
CN-117320730-A Novel therapeutic uses of inhibitors of type 2 iodinated thyronine deiodinase (D2) 谢龙科技有限公司 2023-12-29 CN claimed
CN-117204283-A Corn high-yield cultivation method 十堰市农业科学院 2023-12-12 CN claimed
WO-2023230720-A1 REACTIVE GEL MATERIAL FOR SUSTAINED WATER-BASED REACTIONS EVERBOND INTERFACE TECHNOLOGIES, INC. (CA) 2023-12-07 WO claimed
US-20230276710-A1 PIEZOELECTRIC FILMS INCLUDING IONIC LIQUIDS AND METHODS OF MAKING PIEZOELECTRIC FILMS INCLUDING IONIC LIQUIDS E INK CORPORATION 2023-08-31 US claimed
WO-2023164446-A1 PIEZOELECTRIC FILM INCLUDING IONIC LIQUID AND ELECTROPHORETIC DISPLAY FILM INCLUDING THE PIEZOELECTRIC FILM E INK CALIFORNIA, LLC (US) 2023-08-31 WO claimed
CN-116087381-A Identification method of novel rice based on determination of trace chelating carboxylic acid content 杭州师范大学 2023-05-09 CN claimed
WO-2022263824-A1 METHODS AND COMPOSITIONS XAP THERAPEUTICS LIMITED (GB) 2022-12-22 WO claimed
EP-0133176-B1 PHARMACEUTICAL OR VETERINARY COMPOSITION FOR THE TREATMENT OF ISCHEMIC CARDIAC DISORDERS SANOFI S.A. (FR) 1986-09-03 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260130113-A1 PIEZOELECTRIC FILMS INCLUDING IONIC LIQUIDS AND METHODS OF MAKING PIEZOELECTRIC FILMS INCLUDING IONIC LIQUIDS PIEZO1, MEF2D, CDH1 ABCB1 2432/4885SIRT3 3098/4885KDM5A 2244/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.