Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 4/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537356 | 0.94 | ALDH1A1 (0.64) | ALDH1A1L3MBTL1NAMPTGAAPOLB | |
| SCHEMBL4535924 | 0.88 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1NAMPTGAAPOLB | |
| SCHEMBL4537967 | 0.88 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1GAAPOLBLMNA | |
| SCHEMBL4539044 | 0.88 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1GAAPOLBLMNA | |
| SCHEMBL4537395 | 0.85 | USP30 (0.50) | ALDH1A1L3MBTL1NAMPTGAAMEN1 | |
| SCHEMBL4535742 | 0.85 | NPC1 (0.52) | ALDH1A1L3MBTL1LMNAMEN1KMT2A | |
| SCHEMBL4542202 | 0.84 | KMT2A (0.49) | ALDH1A1L3MBTL1NAMPTGAAPOLB | |
| SCHEMBL4540008 | 0.84 | MEN1 (0.50) | ALDH1A1L3MBTL1NAMPTGAAPOLB | |
| SCHEMBL4542924 | 0.84 | CYP3A4 (0.59) | ALDH1A1L3MBTL1NAMPTGAALMNA | |
| SCHEMBL4540074 | 0.82 | FBP1 (0.50) | ALDH1A1L3MBTL1GAAPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |