Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 3/20 | 0.46 |
| ▸ | F13A1 | P00488 | 1/20 | 0.46 |
| ▸ | TGM1 | P22735 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535453 | 0.94 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1POLBNAMPTGAA | |
| SCHEMBL4538175 | 0.87 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1POLBGAAMEN1 | |
| SCHEMBL4539894 | 0.87 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1POLBMEN1KMT2A | |
| SCHEMBL4533514 | 0.81 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1MEN1KMT2AEPHX1 | |
| SCHEMBL4537967 | 0.81 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1POLBGAAMEN1 | |
| SCHEMBL4539044 | 0.81 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1POLBGAAMEN1 | |
| SCHEMBL4535924 | 0.81 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1POLBNAMPTGAA | |
| SCHEMBL4537395 | 0.79 | USP30 (0.50) | ALDH1A1L3MBTL1NAMPTGAAMEN1 | |
| SCHEMBL4535742 | 0.79 | NPC1 (0.52) | ALDH1A1L3MBTL1PKMMEN1KMT2A | |
| SCHEMBL4541041 | 0.78 | ALDH1A1 (0.62) | ALDH1A1L3MBTL1GAAPKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |