Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.35 |
| ▸ | ACP3 | P15309 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4543601 | 0.86 | AOC3 (0.34) | OPRM1AOC3 | |
| SCHEMBL3703345 | 0.79 | RAB9A (0.39) | AOC3SLC6A2SLC6A4ADRB2ADRB1 | |
| SCHEMBL2578171 | 0.74 | PYCR1 (0.40) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4537987 | 0.72 | CTSA (0.33) | — | |
| SCHEMBL2568706 | 0.70 | MEN1 (0.42) | SLC6A2SLC6A4ACP3SLC6A3RECQL | |
| SCHEMBL3707187 | 0.68 | RAB9A (0.50) | AOC3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3717492 | 0.68 | RAB9A (0.50) | AOC3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3715630 | 0.68 | RAB9A (0.50) | AOC3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2580843 | 0.67 | PYCR1 (0.43) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3705816 | 0.65 | AOC3 (0.50) | AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064269-A1 | COMPOUNDS AND THEIR USE FOR TREATMENT OF Αβ-RELATED DISEASES | ASTRAZENECA AB (SE) | 2012-05-18 | — | — | WO | disclosed |