Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 18/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714125 | 0.79 | RAB9A (0.32) | CTSAMEN1NPC1POLBRAB9A | |
| SCHEMBL4543601 | 0.75 | AOC3 (0.34) | — | |
| SCHEMBL4537085 | 0.72 | OPRM1 (0.36) | — | |
| SCHEMBL4539599 | 0.67 | — | — | |
| SCHEMBL3699960 | 0.65 | CHRM1 (0.32) | — | |
| SCHEMBL4540382 | 0.63 | CTSA (0.39) | CTSA | |
| SCHEMBL3700231 | 0.61 | RAB9A (0.34) | RAB9A | |
| SCHEMBL30968506 | 0.60 | KDM4E (0.40) | NPC1RAB9AKMT2A | |
| SCHEMBL844810 | 0.60 | KDM4E (0.40) | NPC1RAB9AKMT2A | |
| SCHEMBL17018453 | 0.60 | NOS1 (0.42) | CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064269-A1 | COMPOUNDS AND THEIR USE FOR TREATMENT OF Αβ-RELATED DISEASES | ASTRAZENECA AB (SE) | 2012-05-18 | — | — | WO | disclosed |