Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539129 | 0.95 | EPHX2 (0.52) | EPHX2EPHX1CNR1CNR2HSD11B1 | |
| SCHEMBL4539947 | 0.89 | EPHX2 (0.57) | EPHX2EPHX1CNR1CNR2HSD11B1 | |
| SCHEMBL4539701 | 0.89 | HDAC3 (0.47) | EPHX2EPHX1HSD11B1PSMB5NPC1 | |
| SCHEMBL4540405 | 0.87 | HSD11B1 (0.56) | EPHX2EPHX1HSD11B1 | |
| SCHEMBL8062507 | 0.87 | EPHX2 (0.53) | EPHX2EPHX1 | |
| SCHEMBL4537427 | 0.86 | SMN1; SMN2 (0.52) | EPHX2EPHX1NPC1RAB9AKMT2A | |
| SCHEMBL4536856 | 0.86 | KMT2A (0.44) | EPHX1PSMB5NPC1RAB9AKMT2A | |
| SCHEMBL4537575 | 0.84 | ALDH1A1 (0.49) | EPHX2EPHX1RAB9AKMT2AGAA | |
| SCHEMBL4541178 | 0.83 | EPHX1 (0.50) | EPHX2EPHX1HSD11B1PSMB5NPC1 | |
| SCHEMBL4535493 | 0.83 | HDAC3 (0.52) | EPHX2EPHX1HSD11B1PSMB5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |