Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535598 | 0.95 | KMT2A (0.46) | KMT2AMEN1EPHX1L3MBTL1SMN1; SMN2 | |
| SCHEMBL4537222 | 0.90 | KMT2A (0.51) | KMT2AMEN1EPHX1L3MBTL1SMN1; SMN2 | |
| SCHEMBL8066091 | 0.90 | KMT2A (0.51) | KMT2AMEN1EPHX1L3MBTL1SMN1; SMN2 | |
| SCHEMBL4539701 | 0.86 | HDAC3 (0.47) | KMT2AEPHX1L3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL4537439 | 0.86 | EPHX2 (0.48) | KMT2AEPHX1SMN1; SMN2RAB9AGAA | |
| SCHEMBL4539395 | 0.84 | LMNA (0.47) | KMT2AMEN1EPHX1ALDH1A1GAA | |
| SCHEMBL4537427 | 0.84 | SMN1; SMN2 (0.52) | KMT2AEPHX1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL4539287 | 0.83 | HCRTR1 (0.48) | KMT2AMEN1EPHX1L3MBTL1HCRTR1 | |
| SCHEMBL4538146 | 0.83 | CNR1 (0.47) | KMT2AMEN1EPHX1L3MBTL1SMN1; SMN2 | |
| SCHEMBL4541178 | 0.83 | EPHX1 (0.50) | KMT2AEPHX1SMN1; SMN2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |