Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537166 | 0.87 | USP30 (0.50) | EPHX2USP30NPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4539590 | 0.86 | EPHX2 (0.68) | EPHX2 | |
| SCHEMBL4537571 | 0.83 | NPC1 (0.52) | EPHX2USP30NPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL8064542 | 0.83 | USP30 (0.48) | EPHX2USP30NPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4535373 | 0.81 | EPHX2 (0.46) | P2RX7EPHX2SMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL8066384 | 0.81 | USP30 (0.54) | EPHX2USP30 | |
| SCHEMBL4542472 | 0.81 | USP30 (0.54) | EPHX2USP30 | |
| SCHEMBL4537172 | 0.80 | USP30 (0.55) | EPHX2USP30NPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4537421 | 0.80 | EPHX2 (0.59) | EPHX2 | |
| SCHEMBL4537312 | 0.78 | P2RX7 (0.43) | P2RX7USP30KMT2AMEN1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |