Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.34 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.34 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4543897 | 0.81 | POLB (0.50) | L3MBTL1TDP1POLBAPEX1KMT2A | |
| SCHEMBL4540024 | 0.81 | POLB (0.53) | L3MBTL1TDP1POLBAPEX1KMT2A | |
| SCHEMBL4540121 | 0.80 | TDP1 (0.43) | L3MBTL1TDP1POLBAPEX1KMT2A | |
| SCHEMBL4543912 | 0.77 | LMNA (0.49) | L3MBTL1TDP1POLBAPEX1ALDH1A1 | |
| SCHEMBL4543294 | 0.76 | TDP1 (0.67) | L3MBTL1TDP1POLBAPEX1KMT2A | |
| SCHEMBL4542122 | 0.75 | CYP1A2 (0.47) | L3MBTL1TDP1POLBAPEX1KMT2A | |
| SCHEMBL4540551 | 0.72 | POLB (0.50) | L3MBTL1TDP1POLBAPEX1KDM4E | |
| SCHEMBL4543812 | 0.72 | CNR2 (0.46) | POLBLMNATP53MAPT | |
| SCHEMBL4658534 | 0.69 | POLB (0.53) | L3MBTL1TDP1POLBAPEX1KMT2A | |
| SCHEMBL17142873 | 0.69 | SMN1; SMN2 (0.57) | POLBKMT2AMEN1AVPR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |