Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | APEX1 | P27695 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4540024 | 0.81 | POLB (0.53) | TDP1POLBAPEX1L3MBTL1NOTUM | |
| SCHEMBL27895783 | 0.80 | TDP1 (0.50) | TDP1POLBAPEX1L3MBTL1NOTUM | |
| SCHEMBL4543897 | 0.79 | POLB (0.50) | TDP1POLBAPEX1L3MBTL1NOTUM | |
| SCHEMBL4543818 | 0.77 | POLB (0.65) | TDP1POLBAPEX1L3MBTL1ALDH1A1 | |
| SCHEMBL951402 | 0.77 | POLB (0.47) | TDP1POLBAPEX1L3MBTL1LMNA | |
| SCHEMBL4538508 | 0.76 | L3MBTL1 (0.47) | TDP1POLBAPEX1L3MBTL1NOTUM | |
| SCHEMBL4542122 | 0.76 | CYP1A2 (0.47) | TDP1POLBAPEX1L3MBTL1ALDH1A1 | |
| SCHEMBL4787559 | 0.75 | POLB (0.61) | TDP1POLBAPEX1L3MBTL1NOTUM | |
| SCHEMBL30349922 | 0.75 | ALDH1A1 (0.44) | TDP1POLBAPEX1L3MBTL1NOTUM | |
| SCHEMBL4543912 | 0.75 | LMNA (0.49) | TDP1POLBAPEX1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106316975-A | Amide compound and application thereof as TGR5 agonist | 山东轩竹医药科技有限公司 | 2017-01-11 | — | — | CN | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |