Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28556870 | 0.77 | KIF11 (0.47) | MEN1KMT2ATSHRMAPK1HIF1A | |
| SCHEMBL23209634 | 0.76 | MEN1 (0.52) | MEN1KMT2ANPSR1TSHRMAPK1 | |
| SCHEMBL5301475 | 0.76 | MEN1 (0.52) | MEN1KMT2ANPSR1TSHRMAPK1 | |
| SCHEMBL3345076 | 0.76 | KCNN4 (0.54) | KMT2AMAPK1HIF1ACYP1A2CYP2C19 | |
| SCHEMBL1016971 | 0.75 | KMT2A (0.71) | MEN1KMT2ANPSR1TSHRMAPK1 | |
| SCHEMBL26402 | 0.75 | MEN1 (1.00) | MEN1KMT2ANPSR1TSHRMAPK1 | |
| SCHEMBL4297794 | 0.75 | MEN1 (0.71) | MEN1KMT2ANPSR1TSHRMAPK1 | |
| SCHEMBL28652667 | 0.75 | MEN1 (0.52) | MEN1KMT2ANPSR1TSHRMAPK1 | |
| SCHEMBL8743247 | 0.73 | KMT2A (0.68) | MEN1KMT2ANPSR1TSHRMAPK1 | |
| SCHEMBL16312162 | 0.72 | NPSR1 (0.55) | MEN1KMT2ANPSR1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064269-A1 | COMPOUNDS AND THEIR USE FOR TREATMENT OF Αβ-RELATED DISEASES | ASTRAZENECA AB (SE) | 2012-05-18 | — | — | WO | disclosed |