Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4536842 | 0.90 | RAB9A (0.50) | ALDH1A1TP53TSHRRAB9A | |
| SCHEMBL4535933 | 0.90 | PSEN1 (0.56) | ALDH1A1TSHRPSEN1PSEN2APH1B | |
| SCHEMBL4535257 | 0.90 | RAB9A (0.53) | ALDH1A1TP53TSHRPSEN1PSEN2 | |
| SCHEMBL4537565 | 0.90 | RAB9A (0.51) | ALDH1A1RAB9A | |
| SCHEMBL8062041 | 0.88 | RAB9A (0.47) | ALDH1A1RAB9A | |
| SCHEMBL8069510 | 0.87 | BRD4 (0.53) | ALDH1A1 | |
| SCHEMBL4541154 | 0.87 | RAB9A (0.56) | RAB9APAX8 | |
| SCHEMBL4538787 | 0.87 | PSEN1 (0.51) | TSHRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4535339 | 0.87 | ATM (0.47) | RAB9APAX8 | |
| SCHEMBL4542333 | 0.87 | PSEN1 (0.51) | TSHRPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |