Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 5/20 | 0.56 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.56 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.56 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.56 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.56 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4538787 | 0.97 | PSEN1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4542333 | 0.97 | PSEN1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4536842 | 0.90 | RAB9A (0.50) | TSHRALDH1A1 | |
| SCHEMBL4539052 | 0.90 | ALDH1A1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4535257 | 0.90 | RAB9A (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4541043 | 0.90 | ITGB1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4537565 | 0.90 | RAB9A (0.51) | NPSR1ALDH1A1 | |
| SCHEMBL4542596 | 0.89 | MAPT (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4538141 | 0.88 | BDKRB1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4537060 | 0.88 | ALDH1A1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |