Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | CSK | P41240 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.32 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539359 | 0.82 | KDR (0.52) | KDRMAPK14CSKEGFRBRAF | |
| SCHEMBL4364796 | 0.80 | KDR (0.77) | KDR | |
| SCHEMBL4361243 | 0.67 | KDR (1.00) | KDR | |
| SCHEMBL4371470 | 0.65 | LTA4H (0.41) | — | |
| SCHEMBL4364229 | 0.61 | KDR (0.80) | KDREGFR | |
| SCHEMBL4362982 | 0.60 | KDR (1.00) | KDR | |
| SCHEMBL4361692 | 0.60 | KDR (1.00) | KDRMAP3K7 | |
| SCHEMBL4365782 | 0.59 | KDR (0.84) | KDR | |
| SCHEMBL4365818 | 0.59 | KDR (0.66) | KDRBRAF | |
| SCHEMBL13861968 | 0.57 | MEN1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531553-B2 | Heterocyclic compounds and methods of use | AMGEN INC. (US) | 2009-05-12 | — | — | US | disclosed |