SCHEMBL4539391

SCHEMBL4539391

COc1c(OC[C@@H]2CO2)ccc2c1N=C(N)N1CCN=C21

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PTAFR P25105 4/20 0.35
ALDH1A1 P00352 1/20 0.34
GLA P06280 1/20 0.34
PTPN1 P18031 1/20 0.34
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA4 P22748 1/20 0.32
CA7 P43166 1/20 0.32
HDAC8 Q9BY41 2/20 0.32
DRD4 P21917 2/20 0.32
PTGS2 P35354 2/20 0.31
PKM P14618 1/20 0.31
HDAC4 P56524 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4529772 1.00 PTAFR (0.35) PTAFRALDH1A1GLAPTPN1CA1
SCHEMBL4532060 1.00 PTAFR (0.35) PTAFRALDH1A1GLAPTPN1CA1
SCHEMBL4569732 0.91 ALDH1A1 (0.34) ALDH1A1GLACA1CA2CA4
SCHEMBL18928155 0.81 PTAFR (0.36) PTAFRCA1CA2CA4CA7
SCHEMBL18927873 0.81 PTAFR (0.36) PTAFRCA1CA2CA4CA7
SCHEMBL1655758 0.80 PTAFR (0.41) PTAFRALDH1A1
SCHEMBL30137694 0.80 PTAFR (0.41) PTAFRALDH1A1
SCHEMBL12362314 0.78 HDAC8 (0.39) PTAFRCA1CA2CA4CA7
SCHEMBL1655927 0.78 TSHR (0.46) ALDH1A1
SCHEMBL30137704 0.78 KDM4E (0.41) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2638045-B1 AMINOALCOHOL SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS BAYER IP GMBH (DE) 2022-08-31 EP disclosed
US-9902727-B2 Aminoalcohol substituted 2,3-dihydroimidazo[1,2-C]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis BAYER INTELLECTUAL PROPERTY GMBH (DE) 2018-02-27 US disclosed
US-9902727-B2 Aminoalcohol substituted 2,3-dihydroimidazo[1,2-C]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis BAYER INTELLECTUAL PROPERTY GMBH (DE) 2018-02-27 US disclosed
EP-2638044-B1 ALKOXY-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINES BAYER IP GMBH (DE) 2017-08-30 EP disclosed
US-9730943-B2 Alkoxy-substituted 2,3-dihydroimidazo[1,2-C]quinazolines BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-08-15 US disclosed
US-9730943-B2 Alkoxy-substituted 2,3-dihydroimidazo[1,2-C]quinazolines BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-08-15 US disclosed
US-9675616-B2 Arylaminoalcohol-substituted 2,3-dihydroimidazo[1,2-C]quinolines BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-06-13 US disclosed
US-9675616-B2 Arylaminoalcohol-substituted 2,3-dihydroimidazo[1,2-C]quinolines BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-06-13 US disclosed
EP-2638043-B1 ARYLAMINOALCOHOL-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINOLINES BAYER IP GMBH (DE) 2017-06-07 EP disclosed
US-20150080374-A1 AMINOALCOHOL SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-03-19 US disclosed
US-8895549-B2 Aminoalcohol substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-11-25 US disclosed
US-8895549-B2 Aminoalcohol substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-11-25 US disclosed
US-20140113896-A1 ARYLAMINOALCOHOL-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINOLINES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-04-24 US disclosed
US-20140113896-A1 ARYLAMINOALCOHOL-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINOLINES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-04-24 US disclosed
EP-2638043-A1 ARYLAMINOALCOHOL-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINOLINES Bayer Intellectual Property GmbH (DE) 2013-09-18 EP disclosed
EP-2638045-A1 AMINOALCOHOL SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS Bayer Intellectual Property GmbH (DE) 2013-09-18 EP disclosed
EP-2638044-A1 ALKOXY-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINES Bayer Pharma Aktiengesellschaft (DE) 2013-09-18 EP disclosed
WO-2012062745-A1 ALKOXY-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-05-18 WO disclosed
WO-2012062748-A1 AMINOALCOHOL SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-05-18 WO disclosed
WO-2012062743-A1 ARYLAMINOALCOHOL-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINOLINES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-05-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150080374-A1 AMINOALCOHOL SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS PIK3CA, PIK3CD, PIK3C2A PTAFR 839/4885ALDH1A1 2891/4885GLA 2587/4885
US-20140113896-A1 ARYLAMINOALCOHOL-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINOLINES VEGFA, CCNA1, CCND2 PTAFR 891/4885ALDH1A1 105/4885GLA 1245/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.