Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4533110 | 0.86 | HPGD (0.46) | HSD11B1HPGDALDH1A1LMNAGAA | |
| SCHEMBL4539753 | 0.86 | HDAC3 (0.49) | HPGDHTR2AHTR2CALDH1A1LMNA | |
| SCHEMBL8064823 | 0.86 | HPGD (0.46) | HSD11B1HPGDALDH1A1LMNAGAA | |
| SCHEMBL4542831 | 0.83 | ALDH1A1 (0.53) | HPGDALDH1A1PKMLMNAGAA | |
| SCHEMBL4542100 | 0.83 | ALDH1A1 (0.46) | HPGDALDH1A1GAAL3MBTL1 | |
| SCHEMBL4539751 | 0.82 | ATM (0.50) | HSD11B1ATMHTR2AHTR2CKDM4E | |
| SCHEMBL4539846 | 0.82 | JAK2 (0.43) | HPGDALDH1A1LMNAGAAJAK2 | |
| SCHEMBL4542865 | 0.82 | HPGD (0.43) | HSD11B1HPGDALDH1A1LMNAGAA | |
| SCHEMBL4538127 | 0.82 | CCR1 (0.46) | HSD11B1HPGD | |
| SCHEMBL4537337 | 0.81 | ATM (0.46) | HSD11B1ATMHPGDGRM5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |