Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542865 | 0.95 | HPGD (0.43) | HPGDEPHX2P2RX7ALDH1A1CACNA1H | |
| SCHEMBL4533158 | 0.94 | EPHX2 (0.48) | HPGDEPHX2P2RX7ALDH1A1CACNA1H | |
| SCHEMBL8064823 | 0.88 | HPGD (0.46) | HPGDEPHX2P2RX7ALDH1A1CACNA1H | |
| SCHEMBL4539753 | 0.88 | HDAC3 (0.49) | HPGDEPHX2P2RX7ALDH1A1LMNA | |
| SCHEMBL8049830 | 0.86 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL4539563 | 0.86 | EPHX2 (0.56) | EPHX2 | |
| SCHEMBL4539749 | 0.86 | HSD11B1 (0.45) | HPGDALDH1A1LMNAGAAHSD11B1 | |
| SCHEMBL4542831 | 0.85 | ALDH1A1 (0.53) | HPGDEPHX2ALDH1A1LMNAGAA | |
| SCHEMBL4532816 | 0.83 | TP53 (0.48) | ALDH1A1LMNAGAAPOLB | |
| SCHEMBL4538127 | 0.83 | CCR1 (0.46) | HPGDEPHX2P2RX7HSD11B1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |