Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4533116 | 0.85 | EPHX2 (0.50) | L3MBTL1ALDH1A1 | |
| SCHEMBL4539756 | 0.85 | HDAC3 (0.50) | HTR2AHTR2CALDH1A1HSD11B1 | |
| SCHEMBL4539749 | 0.82 | HSD11B1 (0.45) | ATMHTR2AHTR2CCTDSP1TDP1 | |
| SCHEMBL4542832 | 0.82 | ALDH1A1 (0.54) | L3MBTL1PKMALDH1A1 | |
| SCHEMBL4542103 | 0.82 | EPHX2 (0.51) | L3MBTL1USP30ALDH1A1 | |
| SCHEMBL4537339 | 0.82 | ATM (0.49) | ATMCTSLCTSBCTSKALDH1A1 | |
| SCHEMBL4538131 | 0.81 | HDAC3 (0.46) | ALDH1A1HSD11B1 | |
| SCHEMBL4542868 | 0.81 | EPHX2 (0.46) | L3MBTL1ALDH1A1HSD11B1 | |
| SCHEMBL4539847 | 0.81 | USP30 (0.44) | TDP1L3MBTL1USP30JAK2JAK1 | |
| SCHEMBL4542825 | 0.79 | HDAC3 (0.53) | HTR2AHTR2CL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |