Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8066091 | 1.00 | KMT2A (0.51) | KMT2AMEN1EPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4535598 | 0.94 | KMT2A (0.46) | KMT2AMEN1EPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4536856 | 0.90 | KMT2A (0.44) | KMT2AMEN1EPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4539839 | 0.85 | HDAC3 (0.54) | KMT2AEPHX1SMN1; SMN2LMNARAB9A | |
| SCHEMBL4539947 | 0.85 | EPHX2 (0.57) | KMT2AMEN1EPHX1SMN1; SMN2LMNA | |
| SCHEMBL4017211 | 0.84 | EPHX1 (0.56) | KMT2AMEN1EPHX1LMNAL3MBTL1 | |
| SCHEMBL4539287 | 0.83 | HCRTR1 (0.48) | KMT2AMEN1EPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4537540 | 0.83 | HCRTR1 (0.46) | KMT2AMEN1EPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4540917 | 0.82 | LMNA (0.53) | KMT2AMEN1EPHX1ALDH1A1LMNA | |
| SCHEMBL4542094 | 0.82 | NPC1 (0.57) | KMT2AMEN1EPHX1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |