Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.42 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4543065 | 0.95 | EPHX2 (0.48) | EPHX1EPHX2HTTNPSR1LMNA | |
| SCHEMBL4537389 | 0.90 | HTT (0.46) | EPHX1EPHX2HTTNPSR1LMNA | |
| SCHEMBL4539839 | 0.87 | HDAC3 (0.54) | EPHX1EPHX2HTTNPSR1LMNA | |
| SCHEMBL4536605 | 0.86 | LMNA (0.67) | EPHX1EPHX2HTTNPSR1LMNA | |
| SCHEMBL4542374 | 0.84 | HSD11B1 (0.53) | EPHX1EPHX2HTTNPSR1LMNA | |
| SCHEMBL4541686 | 0.84 | HTT (0.45) | EPHX1EPHX2HTTNPSR1LMNA | |
| SCHEMBL4535935 | 0.83 | EPHX2 (0.52) | EPHX1EPHX2HTTNPSR1LMNA | |
| SCHEMBL4540815 | 0.83 | HTT (0.44) | EPHX1EPHX2HTTNPSR1LMNA | |
| SCHEMBL8070996 | 0.82 | HDAC3 (0.52) | EPHX1EPHX2HTTNPSR1LMNA | |
| SCHEMBL4535493 | 0.82 | HDAC3 (0.52) | EPHX1EPHX2HTTNPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |