Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PGD | P52209 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.31 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15698565 | 0.98 | TSHR (0.39) | TSHRPDE4APGDMAPTABCC4 | |
| SCHEMBL629530 | 0.98 | TSHR (0.39) | TSHRPDE4APGDMAPTABCC4 | |
| SCHEMBL27696125 | 0.98 | TSHR (0.39) | TSHRPDE4APGDMAPTABCC4 | |
| SCHEMBL6120459 | 0.96 | TSHR (0.38) | TSHRPDE4APGDMAPTABCC4 | |
| SCHEMBL27702751 | 0.96 | TSHR (0.38) | TSHRPDE4APGDMAPTABCC4 | |
| SCHEMBL28068419 | 0.85 | MAPT (0.42) | TSHRPDE4APGDMAPTABCC4 | |
| SCHEMBL3892239 | 0.83 | MAPT (0.41) | TSHRPDE4APGDMAPTABCC4 | |
| SCHEMBL4538038 | 0.81 | LMNA (0.41) | TSHRMAPTABCC4CYP3A4 | |
| SCHEMBL20819989 | 0.78 | MAPT (0.34) | MAPTABCC4ALDH1A1DDAH1GRIK1 | |
| SCHEMBL22552623 | 0.78 | MAPT (0.34) | MAPTABCC4ALDH1A1DDAH1GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101098859-B | Pyrimidinone compound, preparation and application thereof | ZHEJIANG HISUN PHARM CO LTD | 2013-03-06 | — | — | CN | claimed |
| CN-101098859-A | Pyrimidone compounds and preparation and application thereof | ZHEJIANG HISUN PHARMACEUTICAL (CN) | 2008-01-02 | — | — | CN | claimed |
| CN-1091634-A | The stable pharmaceutical composition that contains a kind of β-Qiang Ji-β-Jia Jiwuersuandanxian coenzyme reductase inhibitor | SANDOZ LTD (CH) | 1994-09-07 | — | — | CN | claimed |
| CN-105431140-A | Complex formulation containing sustained release metformin and immediate release hmg-coa reductase inhibitor | CJ HEALTHCARE CORP | 2016-03-23 | — | — | CN | disclosed |
| CN-101098859-B | Pyrimidinone compound, preparation and application thereof | ZHEJIANG HISUN PHARM CO LTD | 2013-03-06 | — | — | CN | disclosed |
| WO-2012063115-A2 | PROCESS FOR THE PREPARATION OF ROSUVASTATIN CALCIUM VIA NOVEL AMINE INTERMEDIATE | JUBILANT LIFE SCIENCES LTD. (IN) | 2012-05-18 | — | — | WO | disclosed |
| CN-101098859-A | Pyrimidone compounds and preparation and application thereof | ZHEJIANG HISUN PHARMACEUTICAL (CN) | 2008-01-02 | — | — | CN | disclosed |
| CN-1796370-A | Compound substitution heterocycle class | WANG SONGFA (CN) | 2006-07-05 | — | — | CN | disclosed |
| CN-1718573-A | Heterocyclic compound | WANG SONGFA (CN) | 2006-01-11 | — | — | CN | disclosed |
| EP-0403487-A4 | NOVEL HMG-COA REDUCTASE INHIBITORS | — | 1991-06-05 | — | — | EP | disclosed |
| EP-0403487-A1 | NOVEL HMG-CoA REDUCTASE INHIBITORS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1990-12-27 | — | — | EP | disclosed |
| WO-1989005639-A1 | NOVEL HMG-CoA REDUCTASE INHIBITORS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-06-29 | — | — | WO | disclosed |