Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TLR2 | O60603 | 1/20 | 0.33 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542173 | 0.84 | CFTR (0.40) | CFTRMAPTLMNAMEN1KMT2A | |
| SCHEMBL4541733 | 0.78 | CFTR (0.43) | CFTRMAPTLMNAMEN1KMT2A | |
| SCHEMBL4542999 | 0.78 | CFTR (0.42) | CFTRMAPTLMNAMEN1KMT2A | |
| SCHEMBL4544013 | 0.69 | LDHA (0.40) | CFTRMAPTLMNATSHRCYP3A4 | |
| SCHEMBL15523818 | 0.69 | MEN1 (0.39) | CFTRMAPTLMNAMEN1KMT2A | |
| SCHEMBL4542130 | 0.69 | LMNA (0.40) | MAPTLMNAKMT2AHTTCYP3A4 | |
| SCHEMBL4540292 | 0.69 | MAPT (0.64) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL4540140 | 0.68 | MAPT (0.50) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL27267252 | 0.68 | CFTR (0.47) | CFTRMAPTALDH1A1GAAMRGPRX4 | |
| SCHEMBL21258112 | 0.67 | NPC1 (0.40) | MAPTMEN1KMT2AALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |